Medicinal chemistry services include the custom synthesis of small molecule compounds for use in both in vitro and in vivo biological studies. Most compounds can be prepared on a scale of anywhere from 100 mg to 10 grams. Preparation of small libraries of compounds (20-25 analogs at 5-10 mg each) for screening and the development of structure-activity relationships is also available. Compound characterization and analysis includes ¹H NMR, ¹³C NMR, HRMS, and if appropriate, optical rotation.

Note: Prior to any of the following services, the cost of the project will be agreed upon. The total cost will be based on the following services and rates, but will depend upon the nature and complexity of the project.

Medicinal and Synthetic Chemistry Baseline Fees

Synthesis of small molecule tool compounds with purity ≥ 95% by HPLC and ¹H NMR and structure confirmed by ¹H NMR, ¹³C NMR, and HRMS.

Synthesis of 1 to 10 grams (1 gram minimum)

Baseline cost examples

Synthesis of libraries of 10-20 new chemical entity analogs based on a hit and/or lead compound in amounts of 3-10 mg each with purity ≥ 95% by HPLC and ¹H NMR and structure confirmed by ¹H NMR and HRMS.

Synthesis of 20 NCE analogs

Baseline cost examples

• All studies are designed to meet the requirements of the Sponsor, the budget will vary based on multiple design factors such as but not limited to: number of analogs requested complexity of chemical synthesis, number of synthetic steps, cost of requisite building blocks and reagents, number of regions in the scaffold to be scanned, required solvents and volumes of solvents, number and type of purifications, and yield of synthetic transformations.

Formulation Fees

• These are the basic rates, but all studies are designed to meet the requirements of the Sponsor. The actual budget will vary based on multiple factors, including the complexity of the study design and analyses, nature of the compound and formulation, and any additional consultation time needed.

Fees for Basic Ocular Hypertension Study to Evaluate Neuroprotection*

Examples of Add-on Costs (per animal)

*All studies are designed to meet the requirements of the Sponsor, actual study budget will vary based on multiple design factors such as but not limited to: strain of animal being used, animal source/vendor, dose regimen being used, formulation requirements, endpoint parameter(s), study timeline, samples (tissues) and processing, plating media, personnel required, dose route, diagnostic tests (if applicable), number of time points, sample shipment, outsourced tests, method development.

Fees for Testing the Efficacy of Ocular Drug Delivery System*

• These are the basic rates. All studies are designed to meet the requirements of the Sponsor. Thus, services will vary due to the complexity of the analyses, need for method development, sample processing and any additional consultation time needed.